Useful Bioactive Substances from Wastes: Recovery of Trans-Resveratrol from Grapevine Stems

George Angelov*, Lubomir Boyadzhiev, Silviya Georgieva
Institute of Chemical Engineering, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 697
Abstract HTML Views: 604
PDF Downloads: 247
ePub Downloads: 153
Total Views/Downloads: 1701
Unique Statistics:

Full-Text HTML Views: 452
Abstract HTML Views: 357
PDF Downloads: 171
ePub Downloads: 120
Total Views/Downloads: 1100

© Angelov et al. Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Institute of Chemical Engineering, Bulgarian Academy of Sciences, Acad. Bonchev St., Block 103, 1113 Sofia, Bulgaria; Tel: +35929793286; E-mail:


The methods for producing natural resveratrol are of big interest because of the many health benefits of this substance and its increasing use in functional foods, food supplements and para-pharmaceutical preparations. Generally, resveratrol is extracted from different natural sources, most of them usually produced for consumption purposes (grapes, nuts). This paper presents a method for recovery of resveratrol from a widely available raw material - grapevine stems, a by-product of vine pruning. An efficient extraction-fractionation scheme is developed, based on shifting the phase equilibrium, by which more concentrated extracts of resveratrol are obtained. After a simple extraction, the initial extract is further separated into two fractions, containing either water or ethanol-soluble compounds. Using this approach, the resveratrol’s low water solubility helps isolate it from other water-soluble substances. The resulting product is almost ten times more concentrated in trans-resveratrol than the initial total extract. Additionally, a fraction containing water-soluble polyphenols is obtained, which could be used for water-based pharmaceutical and cosmetic preparations.

Keywords: Extraction, grapevine stems, polyphenols, resveratrol.