Investigation on the Pharmacological Activity of Nanoactive Single Components of Ethyl Acetate Extracts of Lamiaceae Plants

Lamiaceae is the name of a family of aromatic plants, which are traditionally used as herbal medicine. There are not many research articles found in the literature regarding the biological study of nanoforms of the Lamiaceaefamily. However in recent years, there were few studies exhibiting the biological properties of plants from the same family. The stem and leaves of three plants from Lamiaceae family of Plectranthus genus, namely Coleus amboinicus Lour, Coleus rotundifolius Lour, and Coleus zeylanicus Lour were subjected to extraction using various solvents with different polarity index. Among the extracts, the ethyl acetate portions were subjected to various pharmacological studies. Through this study, evaluate the antibacterial activities of extracted compounds and their nano forms.

Single compounds were obtained in each extract, which were characterized by UV, IR, and NMR and LC-MS techniques. Nanoporous materials of the same type were prepared by solvothermal and sonication methods. The obtained nanoporous materials were then impregnated on chitosan and their pharmacological evaluation was carried out.

All compounds isolated from the plants show a minimum assay of antibacterial properties in their nanoforms. A better performance was obtained for Coleus zeylanicus Lour.

Selected compounds from plectranthus amboinicus, plectranthus rotundifolius and plectranthus zeylanicus were converted to their nanoforms. These nanoforms were studied by antibacterial analysis. Some of these nanoforms combined with chitosan and their antibacterial activity were studied. Extracted compound from plectranthus zeylanicus using ethyl acetate extract were selected for this study. Bioavailability, chemical potential, nutritive contents and efficiency are the implications of these Compounds. Sustainability, specificity, reproducibility, and solubility of prepared compounds are the limitations of this study.

Chitosan impregnated Coleus zeylanicus Lour had high antibacterial potential against E.coli. growth.