RESEARCH ARTICLE


Optimization of Ultrasound Assisted Extraction of Isoliquiritigenin from Licorice by Response Surface Methodology



Hu Zhiyong*, Zhou Yajing, Xu Xia, Liu Shuyan, Jing Jie
School of Chemical Engineering and Environment, North University of China, Taiyuan, Shanxi 030051, People’s Republic of China


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Creative Commons License
© 2015 Zhiyong et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the School of Chemical Engineering and Environment, North University of China, Taiyuan, Shanxi, 030051; Tel: +86 13994293212; Email: huzhiyong@nuc.edu.cn


Abstract

Isoliquiritigenin (ILG) of licorice is a potential cancer chemopreventive agent. In this paper, response surface methodology (RSM) integrating with Box-Behnken design (BBD) was firstly employed to optimize the ILG extraction, which based on the single-factor experiments. According to analysis, the effect of extraction time and ethanol concentration on yields was significantly. The optimum values were the ethanol concentration of 73.25%, extraction time of 27.82 min and liquid-solid ratio of 19.10: 1. Under these conditions, the highest yield of ILG from licorice was 0.26 mg/g.

Keywords: Response surface methodology, Isoliquiritigenin, Licorice, extraction.