RESEARCH ARTICLE
Optimization of Ultrasound Assisted Extraction of Isoliquiritigenin from Licorice by Response Surface Methodology
Hu Zhiyong*, Zhou Yajing, Xu Xia, Liu Shuyan, Jing Jie
Article Information
Identifiers and Pagination:
Year: 2015Volume: 9
First Page: 149
Last Page: 154
Publisher ID: TOCENGJ-9-149
DOI: 10.2174/1874123101509010149
Article History:
Received Date: 26/05/2015Revision Received Date: 14/07/2015
Acceptance Date: 10/08/2015
Electronic publication date: 22/10/2015
Collection year: 2015
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Isoliquiritigenin (ILG) of licorice is a potential cancer chemopreventive agent. In this paper, response surface methodology (RSM) integrating with Box-Behnken design (BBD) was firstly employed to optimize the ILG extraction, which based on the single-factor experiments. According to analysis, the effect of extraction time and ethanol concentration on yields was significantly. The optimum values were the ethanol concentration of 73.25%, extraction time of 27.82 min and liquid-solid ratio of 19.10: 1. Under these conditions, the highest yield of ILG from licorice was 0.26 mg/g.