Optimization of Ultrasound Assisted Extraction of Isoliquiritigenin from Licorice by Response Surface Methodology

All published articles of this journal are available on ScienceDirect.

RESEARCH ARTICLE

Optimization of Ultrasound Assisted Extraction of Isoliquiritigenin from Licorice by Response Surface Methodology

Hu Zhiyong, * Open Modal Zhou Yajing Xu Xia Liu Shuyan Jing Jie
Authors Info & Affiliations
The Open Chemical Engineering Journal • 22 Oct 2015 • RESEARCH ARTICLE • DOI: 10.2174/1874123101509010149

Abstract

Isoliquiritigenin (ILG) of licorice is a potential cancer chemopreventive agent. In this paper, response surface methodology (RSM) integrating with Box-Behnken design (BBD) was firstly employed to optimize the ILG extraction, which based on the single-factor experiments. According to analysis, the effect of extraction time and ethanol concentration on yields was significantly. The optimum values were the ethanol concentration of 73.25%, extraction time of 27.82 min and liquid-solid ratio of 19.10: 1. Under these conditions, the highest yield of ILG from licorice was 0.26 mg/g.

Keywords: Response surface methodology, Isoliquiritigenin, Licorice, extraction.